Quantification of Melanoma mRNA Markers in Sentinel Nodes
نویسندگان
چکیده
منابع مشابه
Immune response markers in sentinel nodes may predict melanoma progression
We recently reported that variable expression of immune-response genes distinguishes tumor positive sentinel nodes in melanoma patients with malignant progression from those with non-progressing disease. Our results depict sentinel nodes as sites in which immune functions are associated with metastatic disease and identify CD30 as a host immune-related cancer prognostic marker and potential the...
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As a concept sentinel lymph node biopsy seems attractive in that it attempts to identify the first lymph node, rather than the nearest node, draining a particular anatomic area where a tumour has arisen. Pathological assessment can then indicate whether metastases are present and the procedure is either a strong prognostic indicator or possibly therapeutic in itself. These comments apply to any...
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BACKGROUND Any sentinel lymph node that receives lymph drainage directly from a primary melanoma site, regardless of its location, may contain metastatic disease. This is true even if the sentinel node does not lie in a recognized node field. Interval (in-transit) nodes that lie along the course of a lymphatic vessel between a primary melanoma site and a recognized node field are sometimes seen...
متن کاملHistopathological patterns of melanoma metastases in sentinel lymph nodes.
AIMS Sentinel lymph node biopsy (SLNB) is an important component in the staging and treatment of cutaneous melanoma (CM). The medical literature provides only limited information regarding melanoma sentinel lymph node (SLN) histology. This report details the specific histological patterns of melanoma metastases in sentinel lymph nodes (SLNs) and highlights some key factors in evaluating SLNs fo...
متن کاملHuman Langerhans cells are immature in melanoma sentinel lymph nodes.
Human Langerhans cells are immature in melanoma sentinel lymph nodes The specific function of Langerhans cells (LCs) in the skin immune system is controversial and a matter of intense debate. 1 As epidermal LCs are potential targets for cancer immuno-therapy, the topic is of primary importance. 2 Recently, van de Ven et al showed that LCs are phenotypically mature, 3 but, surprisingly, function...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2004
ISSN: 1525-1578
DOI: 10.1016/s1525-1578(10)60518-1